Eukaryotic Promoter Recognition
نویسندگان
چکیده
منابع مشابه
Eukaryotic promoter recognition.
On ly recen tly h as it becom e common to determ in e eukaryotic gen om ic sequen ces large en ough to con tain several gen es. With th ese data com es a n ew problem for gen e fin din g program s: to partit ion a set of exon s correctly am on g several gen es. On e lin e of developm en t in eukaryot ic gen e iden tification begin s with codin g region iden tificat ion by statist ical m ean s a...
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MOTIVATION We describe a new content-based approach for the detection of promoter regions of eukaryotic protein encoding genes. Our system is based on three interpolated Markov chains (IMCs) of different order which are trained on coding, non-coding and promoter sequences. It was recently shown that the interpolation of Markov chains leads to stable parameters and improves on the results in mic...
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The Eukaryotic Promoter Database (EPD) is an annotated non-redundant collection of experimentally characterised eukaryotic POL II promoters. The underlying definition of a promoter is that of a transcription initiation site. All information presented in EPD results from an independent evaluation of primary experimental data shown in the biological literature. Sequences flanking transcription in...
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We present an approach to integrate physical properties of DNA, such as DNA bendability or GC content, into our probabilistic promoter recognition system McPROMOTER. In the new model, a promoter is represented as a sequence of consecutive segments represented by joint likelihoods for DNA sequence and profiles of physical properties. Sequence likelihoods are modeled with interpolated Markov chai...
متن کاملRapid synthesis of defined eukaryotic promoter libraries.
Current gene synthesis methods allow the generation of long segments of dsDNA. We show that these techniques can be used to create synthetic regulatory elements and describe a method for the creation of completely defined, synthetic variants of the PHO5 promoter from the budding yeast Saccharomyces cerevisae. Overall, 128 promoters were assembled by high-temperature ligation, cloned into plasmi...
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ژورنال
عنوان ژورنال: Genome Research
سال: 1997
ISSN: 1088-9051,1549-5469
DOI: 10.1101/gr.7.9.861